منابع مشابه
Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis.
Infections with Shiga toxin (STx)-producing bacteria cause more than a million deaths each year and have no definitive treatment. To exert its cytotoxic effect, STx invades cells through retrograde membrane trafficking, escaping the lysosomal degradative pathway. We found that the widely available metal manganese (Mn(2+)) blocked endosome-to-Golgi trafficking of STx and caused its degradation i...
متن کاملAntihistamine Toxicosis
Antihistamines are H1-receptor antagonists widely used in human and veterinary medicine to provide symptomatic relief of allergic signs caused by histamine release, including pruritus and anaphylactic reactions. Antihistamines are also commonly used as sedatives and antiemetics. 1 Antihistamines can be divided into first and second-generation (also called nonsedating) agents (Table 1). First-ge...
متن کاملDiazinon Toxicosis in Geese
On a goose farm with 7600 geese kept in 6 houses, 730 birds in 2 houses died within a single day. After drinking, a certain proportion of geese in the affected houses exhibited trembling, salivation, lachrymation and respiratory distress followed by convulsions, dullness and prostration. The birds died soon after the onset of clinical signs. Postmortem examination revealed the presence of a lar...
متن کاملTall Fescue Toxicosis
widely used forage crop. It is insect and nematode resistant, tolerates poor soil and climatic conditions well and has a long growing season. Unfortunately, tall fescue also has a downside. Most tall fescue in the state is infected with a fungal endophyte, Neotyphodium coenophialum (formerly called Acremonium coenophialum) that is toxic to animals. Tall fescue was brought to this country from E...
متن کاملPermethrin toxicosis in cats.
A retrospective analysis of all adverse experience reports received by the Australian Pesticides and Veterinary Medicines Authority's Adverse Experience Reporting Program for veterinary medicines since 1995, showed that permethrin toxicity in cats usually occurred after the owner applied a canine permethrin-containing product, typically a spot-on. Cats are also at risk from grooming or being in...
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ژورنال
عنوان ژورنال: JAMA: The Journal of the American Medical Association
سال: 1913
ISSN: 0098-7484
DOI: 10.1001/jama.1913.04350130036012